A master’s thesis was discussed at the Faculty of Medicine /University of Kufa. Marwa Ali Kadhum, the student from the department of Pharmacology and therapies tagged her thesis as (Effect of Topically Applied Simvastatin, Luteolin and there combination with Minoxidil solution for Enhancement of hair growth in male mice). The study aimed to compare the effect of topical application of simvastatin, simvastatin and minoxidil, luteolin, luteolin and minoxidil with an active control group (minoxidil solution alone) on promoting hair growth, measuring lipid peroxidation and oxidative stress markers (total activity of antioxidants) by ELISA assay in animal model and to evaluate its effectiveness. According to the overall results of the study, it was proven that the use of all minoxidil, simvastatin, and luteolin significantly improved hair growth and increased the number of hairs and increased follicles. It has also been shown to increase the overall antioxidant activity, a vascular endothelial growth factor, and a keratinocyte growth factor, through antioxidant and antiestrogen activities in male mice.