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PhD thesis on a (immunohistochemical and molecular study of Adenomatous Polyposis Coli (APC) Gene in colorectal carcinoma and precancerous colorectal Lesions in sample of Iraqi people

The thesis was submitted by Adeeb AbdulAli Abdul Hussein, the postgraduate student at the Department of Pathology, Faculty of Medicine at the University of Kufa.In the study, a pioneer investigation (in Iraq) was conducted to clarify the proposed prevalence of APC gene alteration in colorectal carcinoma , to predict its malignant potential in precancerous lesions through both immunohistological  and  polymerase chain reaction techniques and to study the frequency of molecular changes in APC gene in colorectal carcinoma development.The study concludes that APC gene alteration is well correlated with biological aggressiveness of colorectal tumors.

 

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